Second-placed Sevilla were held to a 1-1 draw by Barcelona, while Juventus registered a routine 2-0 win over struggling Cagliari.
Barcelona defender Gerard Pique blamed the club's pre-season trips to the United States and Japan for their shaky start to the season.
Barcelona winger Raphinha secured a 1-0 win in LaLiga for the second straight week this time at Athletic Bilbao as his side tightened their grip on top spot.
Bayern Munich coach Pep Guardiola is now backing his former club Barcelona.
Robert Lewandowski and substitute Pablo Torre each scored twice to help leaders Barcelona thrash visitors Sevilla 5-1 in LaLiga on Sunday in a confidence boost for Hansi Flick's side ahead of key clashes against Bayern Munich and Real Madrid.
Barcelona's Lionel Messi scored twice in a 3-0 win over Las Palmas in a match played without fans following clashes between police and voters in Catalonia over a disputed independence referendum.
Kylian Mbappe was in inspired form, scoring twice to guide Real Madrid to a comeback 4-1 win over visitors Las Palmas on Sunday.
Real Madrid showed their character by beating Barcelona 2-0 in Sunday's top-of-the-table 'Clasico', leapfrogging their rivals at the La Liga summit after a week in which their pride had taken a beating at home and in Europe. Brazilian teenager Vinicius Jr scored the opener in the 71st minute with a strike that deflected off Gerard Pique, flummoxing goalkeeper Marc-Andre ter Stegen who had made some jaw-dropping saves, and substitute Mariano added the second in added time.
Ronaldinho struck twice as he steered Barcelona to a 3-0 home win over Recreativo Huelva.
LaLiga leaders Real Madrid's pursuit of a record-extending 36th Spanish title
Former world No. 1 Kidambi Srikanth's wretched run continued as he went down 6-21, 17-21 to fellow-Indian Ajay Jayaram, diminishing his hopes of qualifying for the Tokyo Games.
A round-up of Wednesday's action in the UEFA Champions League.
IMAGES from football matches played across Europe on Wednesday.
Roundup of the matches being held across major football leagues in Europe on Sunday
Messi scored twice and created goals for Arturo Vidal and Luis Suarez as champions Barca moved top of the table with 22 points from 10 matches.
Sergio Aguero scored a dramatic late winner as Atletico Madrid twice came from behind to stun visiting Barcelona 4-3 on Sunday, leaving the Catalans just four points clear at the top in Spain.
A summary of Saturday's action in the LaLiga, Serie A and Bundesliga.
Barcelona striker Neymar is confident the Catalans can launch another remarkable Champions League comeback as they look to overturn a 3-0 quarter-final deficit against Juventus on Wednesday.
Lionel Messi lifted Barcelona out of their recent slump with two goals in a vintage display as his side survived a tenacious Tottenham Hotspur fightback to claim a 4-2 victory in Champions League Group B on Wednesday.
Jude Bellingham converted a penalty and Kylian Mbappe added another goal before halftime to spur Real Madrid to a 2-0 victory over Getafe.
Spain striker Iago Aspas dealt a fresh blow to Barcelona's La Liga title hopes by striking a late free kick to snatch a 2-2 draw at home to the Catalans on Saturday as Quique Setien's side twice threw away the lead in a thrilling match. The draw put Barca back on top of the table on 69 points after 32 games but Real Madrid, on 68, can go two points clear at the summit if they beat Espanyol away from home on Sunday.
Barcelona coach Luis Enrique had a nerve-racking experience having to watch their stellar run from the sidelines.
A summary of Wednesday's action in the Champions League quarter-finals first leg.
Pierre-Emerick Aubameyang scored twice as a rejuvenated Barcelona gave a football masterclass to inflict a humiliating 4-0 defeat on rivals Real Madrid on Sunday.
Lionel Messi celebrated his sixth Ballon D'Or award with a brilliant hat-trick as Barcelona moved back top of La Liga with an emphatic 5-2 victory over Real Mallorca.
Barcelona top the LaLiga standings with 15 points, four ahead of Real Madrid and Villarreal. Girona are seventh on seven points.
Barcelona crashed out of the Champions League following a 3-0 defeat at Bayern Munich on Wednesday, failing to make it past the group stage of the competition for the first time since the 2000-01 season.
Mercedes have called in the police after an anonymous email purporting to be from an insider accused the Formula One team of sabotaging their departing seven times world champion Lewis Hamilton
Barcelona take a 32-match unbeaten run to Arsenal for the first leg of their Champions League last 16 tie on Tuesday as the Catalans continue their bid to become the first team to retain the trophy in 26 years.
IMAGES from the UEFA Champions League matches played on Wednesday.
Real Madrid manager Carlo Ancelotti said on Saturday he is happy with how new signing Kylian Mbappe is settling into life with the Spanish soccer giants and he has no concerns about his team's slow start to the LaLiga season.
Cristiano Ronaldo struck twice on his return from suspension as Real Madrid crushed bottom side Xerez 3-0 away in La Liga on Saturday and trimmed Barcelona's lead at the top to two points.
Napoli thrash Palermo to advance to Coppa Italia last 16
A summary of Wednesday's Champions League Round of 16, Second Leg, matches.
Barcelona striker Robert Lewandowski scored twice to set his side on course for a 5-0 Champions League thrashing of Swiss side Young Boys on Tuesday as the Catalan giants bounced back from a 2-1 loss at AS Monaco in their opener.
Rafael Nadal won a record-extending 10th Barcelona Open title on Sunday by thrashing Dominic Thiem of Austria 6-4, 6-1, collecting his second claycourt title in a row.
Unstoppable duo Andres Iniesta and Lionel Messi helped Barcelona thrash Sevilla 5-0 to win the King's Cup final for the fourth consecutive season on Saturday as they close in on a likely domestic double.
Kylian Mbappe scored twice in the second half to help his side to a 4-1 comeback win at 10-man Barcelona
The following is the draw for the Champions League last 16 which was held in Nyon on Monday:
All the action from football matches played in Europe on Wednesday
